Selective pressures on genomes in molecular evolution

We describe the evolution of macromolecules as an information transmission process and apply tools from Shannon information theory to it. This allows us to isolate three independent, competing selective pressures that we term compression, transmission, and neutrality selection. The first two affect genome length: the pressure to conserve resources by compressing the code, and the pressure to acquire additional information that improves the channel, increasing the rate of information transmission into each offspring. Noisy transmission channels (replication with mutations) gives rise to a third pressure that acts on the actual encoding of information; it maximizes the fraction of mutations that are neutral with respect to the phenotype. This neutrality selection has important implications for the evolution of evolvability. We demonstrate each selective pressure in experiments with digital organisms.

Evolution of differentiated expression patterns in digital organisms

We investigate the evolutionary processes behind the development and optimization of multiple threads of execution in digital organisms using the avida platform, a software package that implements Darwinian evolution on populations of self-replicating computer programs. The system is seeded with a linearly executed ancestor capable only of reproducing its own genome, whereas its underlying language has the capacity for multiple threads of execution (i.e., simultaneous expression of sections of the genome.) We witness the evolution to multi-threaded organisms and track the development of distinct expression patterns. Additionally, we examine both the evolvability of multi-threaded organisms and the level of thread differentiation as a function of environmental complexity, and find that differentiation is more pronounced in complex environments.